The Journey to R4D: An institutional history of an Australian Initiative on Food Security in Africa

Internal Revie

Alaska: Glaciers of Kenai Fjords National Park and Katmai National Park and Preserve

There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2,276 sq km of park land (ca. 2000). There are two primary glacierized areas in KEFJ (the Harding Icefield and the Grewingk-Yalik Glacier Complex) and three primary glacierized areas in KATM (the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area, and the Mt. Martin area). Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from2000. Landsat Multispectral Scanner (MSS),Thematic Mapper (TM), and Enhanced Thematic Mapper Plus (ETM) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image-processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS)outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or 1.5(from 1986 to 2000), and 76 sq km, or 7.7 (from19861987 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include debris cover(moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS,TM, or ETM sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 34. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including 15 min USGS quadrangle maps(19501951), Landsat imagery (19861987, 2000,2006), and 2005 IKONOS imagery (KEFJ only)

Alaska: Glaciers of Kenai Fjords National Park and Katmai and Lake Clark National Parks and Preserve

There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2276 sq km of park land (circa 2000). There are two primary glacierized areas in KEFJ -- the Harding Icefield and the Grewingk-Yalik Glacier Complex, and three primary glacierized areas in KATM - the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area and the Mt. Martin area. Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from 2000. Landsat Multispectral Scanner (MSS), Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS) outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or -1.5% (from 1986 to 2000), and 76 sq km, or -7.7% (from 1986/87 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include: debris-cover (moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS and TM or ETM+ sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 3-4%. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including the 15-minute USGS quadrangle maps (1950/1951), Landsat imagery (1986/1987, 2000, 2006) and 2005 Ikonos imagery (KEFJ only)

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye

Aging is associated with increased risk of ocular disease, suggesting that age-associated molecular changes in the eye increase its vulnerability to damage. Although there are common pathways involved in aging at an organismal level, different tissues and cell types exhibit specific changes in gene expression with advanced age. Drosophila melanogaster is an established model system for studying aging and neurodegenerative disease that also provides a valuable model for studying age-associated ocular disease. Flies, like humans, exhibit decreased visual function and increased risk of retinal degeneration with age. Here, we profiled the aging proteome and metabolome of the Drosophila eye and compared these data with age-associated transcriptomic changes from both eyes and photoreceptors to identify alterations in pathways that could lead to age-related phenotypes in the eye. Of note, the proteomic and metabolomic changes observed in the aging eye are distinct from those observed in the head or whole fly, suggesting that tissue-specific changes in protein abundance and metabolism occur in the aging fly. Our integration of the proteomic, metabolomic, and transcriptomic data reveals that changes in metabolism, potentially due to decreases in availability of B vitamins, together with chronic activation of the immune response, may underpin many of the events observed in the aging Drosophila eye. We propose that targeting these pathways in the genetically tractable Drosophila system may help to identify potential neuroprotective approaches for neurodegenerative and age-related ocular diseases. Data are available via ProteomeXchange with identifier PXD027090

Reproducibility of hospital rankings based on centers for Medicare & Medicaid Services Hospital Compare measures as a function of measure reliability

Importance: Unreliable performance measures can mask poor-quality care and distort financial incentives in value-based purchasing. Objective: To examine the association between test-retest reliability and the reproducibility of hospital rankings. Design, Setting, and Participants: In a cross-sectional design, Centers for Medicare & Medicaid Services Hospital Compare data were analyzed for the 2017 (based on 2014-2017 data) and 2018 (based on 2015-2018 data) reporting periods. The study was conducted from December 13, 2020, to September 30, 2021. This analysis was based on 28 measures, including mortality (acute myocardial infarction, congestive heart failure, pneumonia, and coronary artery bypass grafting), readmissions (acute myocardial infarction, congestive heart failure, pneumonia, and coronary artery bypass grafting), and surgical complications (postoperative acute kidney failure, postoperative respiratory failure, postoperative sepsis, and failure to rescue). Exposures: Measure reliability based on test-retest reliability testing. Main Outcomes and Measures: The reproducibility of hospital rankings was quantified by calculating the reclassification rate across the 2017 and 2018 reporting periods after categorizing the hospitals into terciles, quartiles, deciles, and statistical outliers. Linear regression analysis was used to examine the association between the reclassification rate and the intraclass correlation coefficient for each of the classification systems. Results: The analytic cohort consisted of 28 measures from 4452 hospitals with a median of 2927 (IQR, 2378-3160) hospitals contributing data for each measure. The hospitals participating in the Inpatient Prospective Payment System (n = 3195) had a median bed size of 141 (IQR, 69-261), average daily census of 70 (IQR, 24-155) patients, and a median disproportionate share hospital percentage of 38.2% (IQR, 18.7%-36.6%). The median intraclass correlation coefficient was 0.78 (IQR, 0.72-0.81), ranging between 0.50 and 0.85. The median reclassification rate was 70% (IQR, 62%-71%) when hospitals were ranked by deciles, 43% (IQR, 39%-45%) when ranked by quartiles, 34% (IQR, 31%-36%) when ranked by terciles, and 3.8% (IQR, 2.0%-6.2%) when ranked by outlier status. Increases in measure reliability were not associated with decreases in the reclassification rate. Each 0.1-point increase in the intraclass correlation coefficient was associated with a 6.80 (95% CI, 2.28-11.30; P = .005) percentage-point increase in the reclassification rate when hospitals were ranked into performance deciles, 4.15 (95% CI, 1.16-7.14; P = .008) when ranked into performance quartiles, 1.47 (95% CI, 1.84, 4.77; P = .37) when ranked into performance terciles, and 3.70 (95% CI, 1.30-6.09; P = .004) when ranked by outlier status. Conclusions and Relevance: In this study, more reliable measures were not associated with lower rates of reclassifying hospitals using test-retest reliability testing. These findings suggest that measure reliability should not be assessed with test-retest reliability testing

CP violation in J/ψ→ΛΛˉJ/\psi \rightarrow \Lambda \bar \Lambda

We study CP violation in $J/\psi \rightarrow \Lambda \bar{\Lambda}$ decay. This decay provides a good place to look for CP violation. Some observables are very sensitive to the $\Lambda$ electric dipole moment $d_\Lambda$ and therefore can be used to improve the experimental upper bound on $d_\Lambda$. CP violations in the lepton pair decays of $J/\psi$ and $\Upsilon$ are also discussed.Comment: 8 pages, RevTex, UM-P-92/113, OZ-92/3

Ground Laboratory Soft X-Ray Durability Evaluation of Aluminized Teflon FEP Thermal Control Insulation

Metallized Teflon fluorinated ethylene propylene (FEP) thermal control insulation is mechanically degraded if exposed to a sufficient fluence of soft x-ray radiation. Soft x-ray photons (4-8 A in wavelength or 1.55 - 3.2 keV) emitted during solar flares have been proposed as a cause of mechanical properties degradation of aluminized Teflon FEP thermal control insulation on the Hubble Space Telescope (HST). Such degradation can be characterized by a reduction in elongation-to-failure of the Teflon FEP. Ground laboratory soft x-ray exposure tests of aluminized Teflon FEP were conducted to assess the degree of elongation degradation which would occur as a result of exposure to soft x-rays in the range of 3-10 keV. Tests results indicate that soft x-ray exposure in the 3-10 keV range, at mission fluence levels, does not alone cause the observed reduction in elongation of flight retrieved samples. The soft x-ray exposure facility design, mechanical properties degradation results and implications will be presented